Abrishami 5, Brian F. Our study demonstrates that HFD causes long-term, persistent changes in bone quality. It is well established that high-fat feeding of mice leads to a reduction in cancellous bone mass 7, 12, 21, This positive correlation is stronger in women than in men and in postmenopausal than in premenopausal women. Pongchaiyakul, J. Obesity and fractures. About this article Cite this article Wohl, G. Diet, however, did affect cancellous bone composition. J Periodontal Res 44 1 —
A correlation between obesity and bone metabolism is strongly assumed because adipocytes and osteoblasts originate from the same precursor cells and their differentiation is conversely regulated by the same factors. It is controversially discussed if obesity protects bone or leads to loss of bone mass. The cancellous bone mass, collagen 1 1 expression, amount of osteoid, and cohesion of cells via cell-to-cell contacts decreased in HFD mice whereas the bone mineral density and the amount of osteoblasts and osteoclasts were not modified. The amount of apoptotic osteocytes was increased in HFD mice in comparison to controls. We conclude that moderately increased body weight does not protect bone architecture from age-dependent degeneration. By contrast, bone microstructure is negatively affected and reduced maintenance of cell-cell contacts may be one of the underlying mechanisms. Globally, estimated million adults and million children were classified as overweight or obese in and the rates of obesity are still increasing [ 2 ]. Obesity is associated with many chronic disorders such as type 2 diabetes mellitus, coronary heart disease, sleep-breathing disorders, certain cancers, and osteoarthritis [ 1 ]. A correlation between obesity and bone metabolism is strongly assumed. Bone forming osteoblasts are derived from stem cells that can also give rise to adipocytes and chondrocytes [ 3 ]. Stem cells proliferate and differentiate into preosteoblasts and finally into mature osteoblasts that are characterized by cessation of cell division, production of bone matrix, and synthesis of several essential marker enzymes and proteins for bone formation, for example, collagen type 1, osteocalcin, and alkaline phosphatase ALP. In lamellar bone, its fiber organization allows the highest density per unit volume of tissue.
After these dietary challenges, the tibia and femur were removed and analyzed by micro computed-tomography for bone morphology. The direct comparison between these results is not possible because of the different methods and the different HFDs. Dempster, J. The amount of apoptotic osteocytes was increased in HFD mice in comparison to controls. The direct effect of the HFD on bone at the messenger RNA level in progenitor cells isolated from femoral bone marrow was a significantly increased expression of adipogenic marker genes v. References P.